منابع مشابه
Selective antagonism of humoral versus neural vasoconstrictor responses by nisoldipine.
The effects of nisoldipine administration on vascular reactivity to humoral and neural vasoconstrictor stimuli were examined in the intact rat. For these experiments, rats were instrumented with miniaturized pulsed Doppler flow probes to allow continuous measurement of renal, mesenteric, and hindquarters blood flow. In conscious and anesthetized rats, intravenous doses of angiotensin II (75 and...
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Insulin can trigger metabolic as well as mitogenic effects, the latter being pharmaceutically undesirable. An understanding of the structure/function relationships between insulin receptor (IR) binding and mitogenic/metabolic signalling would greatly facilitate the preclinical development of new insulin analogues. The occurrence of ligand agonism and antagonism is well described for G protein-c...
متن کاملInsulin stimulated phagocytic ability and humoral immunologic response in mice.
Female CBA mice, six months old, have been used. Crystalline insulin (Pliva, Zagreb) was injected s.c, 0,25, 0,5, 1 or 1,5 I.U./mouse/day for 10 days. Since the alterations of the immunological functions after various doses of insulin were not essentialy different, we shall present only the data obtained after treatment with 1 I.U. These doses did not cause any mortality from hypoglycemia. The ...
متن کاملAntagonism of Insulin Action on Muscle by the Albumin-bound B Chain of Insulin.
1. The presence of a substance associated with human albumin that exerts anti-insulin activity on the isolated rat diaphragm has been confirmed. This factor has been removed from albumin, thereby providing a source of non-antagonistic carrier protein. 2. Derivatives of the polypeptide B chain of insulin obtained by chemical scission of the interchain disulphide bonds have been separated by conv...
متن کاملHumoral and Mucosal-Humoral Immune Response to a Salmonella Vaccina
Although vaccination against Salmonella has been used more frequently in broiler breeders in recent years, there is limited information in the literature demonstrating the immunological response of combinations of live and killed whole cell vaccines. The present research assesses the immunological response generated by three different vaccination protocols. Treatment vaccines consisted of a liv...
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ژورنال
عنوان ژورنال: Diabetes
سال: 1956
ISSN: 0012-1797,1939-327X
DOI: 10.2337/diab.5.4.321